Listen to Understand

We investigate the world of Biochemistry and Tech-driven Health Care

How Drug Development Guru Mark Eller Went From AI/ML Skeptic to Supporter

Moneyball Medicine®

How does an expert in pharmacokinetics, whose only exposure to computers was taking one semester of programming in college to meet a language requirement, become an advocate for the new AI-driven style of drug discovery? This week Harry finds out from Mark Eller, who helped to invent Allegra at Hoechst Marion Roussel (now Sanofi), spent 12 years at Jazz Pharmaceuticals; and is now senior vice president of research and development at twoXAR, an AI-driven drug discovery startup.

41 min 59 sec

Rhoda Au on Digital Biomarkers and Precision Brain Health


Moneyball Medicine®

Harry speaks with Boston University’s Rhoda Au, who believes that algorithms parsing new kinds of digital data about individual patients could find warning signs of diseases like dementia while they’re still preventable—leading to a new era in which precision medicine is gradually replaced by “precision health.”

39 min 35 sec

Kathryn Teng on Unlocking the Puzzle of Population Health


Moneyball Medicine®

Harry has a heart-to-heart conversation with Dr. Kathryn Teng, who’s working to use data to implement an access- and experience-based population health model at MetroHealth, the public health system for Cuyahoga County, Ohio.

39 min 23 sec

Alán Aspuru-Guzik and the Revolution in Molecular Design


Moneyball Medicine®

Harry gets an update on the merger of AI, robotics, and high-throughput chemistry in the new "self-driving laboratory" from University of Toronto theoretical chemist Alán Aspuru-Guzik.

30 min 53 sec

Jennifer Carter and the Power of Individualized Cancer Care


Moneyball Medicine®

This week Harry learns about the power of individualized molecular diagnostics for cancer patients from N-of-One founder Jennifer Levin Carter.

42 min 21 sec

Mark Boguski on Antidotes to Overspecialization in Medicine


Moneyball Medicine®

Dr. Mark Boguski argues in this week's episode that diagnostic management teams consisting of physicians from diverse specialties, including genetics and genomics, can integrate data from different specialties and improve patient care.

37 min 48 sec

Sandy Aronson on AI and Gene-based Personalized Medicine (AI World Special Series Part 2)


Moneyball Medicine®

Sandy Aronson from Partners HealthCare Personalized Medicine argues that "algorithm-enhanced care" is helping physicians make better decisions.

41 min 49 sec

Aalpen Patel and Using AI to Reduce Time-to-Diagnosis (AI World Special Series Part 1)


Moneyball Medicine®

Harry talks wth Geisinger's Dr. Aalpen Patel about machine-learning algorithms that can help radiologists read CT scans and speed up diagnosis of urgent conditions.

34 min 36 sec

Massimo Buscema on AI and What We Can and Can't See in the Human Body


Moneyball Medicine®

Harry's guest in this episode is Massimo Buscema, director of the Semeion Research Center in Rome, Italy, and a full professor at the University of Colorado at Denver. Buscema researches and consults internationally on the theory and applications of AI, artificial neural networks, and evolutionary algorithms. The conversation focuses on AI and its applications in healthcare, and how it can enhance what we can see and uncover what we cannot.

37 min 00 sec

Barrett Rollins and the DNA-driven Transformation of Oncology


Moneyball Medicine®

Harry's guest for this episode is Dr. Barrett Rollins, the chief scientific officer and faculty dean for academic affairs at Boston's Dana Farber Cancer Institute and the Linde Family Professor of Medicine at Harvard Medical School. Harry and Dr. Rollins dig into how large-scale DNA analysis can one day put much more usable information into the hands of oncologists, and how that data affects individual patients, the practice of medicine, and new therapies under development.

30 min 27 sec

Joel Dudley and What Happens When You Let Data—Not Hypotheses—Drive Discovery


Moneyball Medicine®

Harry's guest this week is Dr. Joel Dudley from the Icahn School of Medicine at Mount Sinai, where he serves as executive vice president of precision health, associate professor of genetics and genomic sciences, and founding director of the Institute for Next Generation Healthcare. Dr. Dudley explains how his group is utilizing data to uncover health problems that can't be detected through normal methods, as well as his groundbreaking paper on the link between Alzheimer's disease and herpes.

29 min 00 sec